Procollagen messenger RNA levels and activity and collagen synthesis during the fetal development of sheep lung, tendon, and skin.

摘要: The rates of type I collagen synthesis in sheep lung, tendon, and skin were evaluated during the latter half fetal development compared with levels procollagen mRNA, quantified by molecular hybridization a specific complementary DNA, activity total mRNA measured vitro cell-free translation. In lung parallel development. skin, however, declines sharply development, but both remain at high early These observations suggest that developing are likely major determinants synthesis. contrast, dichotomy between utilizes mechanisms addition to modulate expression gene.