Effects of quinine on gastric ulcer healing in Wistar rats.
作者： Olasupo Stephen Adeniyi , Olubiyi Vincent Makinde , Emmanuel Titus Friday , Samuel Babafemi Olaleye , None
关键词:
摘要: Background Quinine (QT) is an important anti-malarial drug; however, there little information about its effects on the gut. Therefore, this study aimed to investigate of a therapeutic dose QT healing gastric ulcer in rats. Methods Male Wistar rats weighing 150-200 g were divided into three groups: control without (group 1), ulcerated treated with 1 mL/kg (p.o.) normal saline (NS) 2), and 10 mg/kg 3). Ulcers induced by serosal application 80 % acetic acid stomach anaesthetized 50 thiopentone sodium treatment was given times daily. Healing assessed days 3, 7 after induction macroscopic measurement of: area, histology, lipid peroxidation, superoxide dismutase activity mucus secretion. Results At day no significant difference (p>0.05) areas between NS- QT-treated By 10, percentage area healed NS (59.6±2.35 %) significantly higher (p<0.05) than (49.0±2.20 clearing inflammatory cells re-epithelization greater NS-treated group. peroxidation animals, when compared controls (p<0.05). Superoxide secretion Conclusions delayed prolonging phase healing, increasing oxidative stress, reducing antioxidant
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