Serum 3α-Androstanediol Glucuronide Measurements in Sexually Mature Women with Congenital Adrenal Hyperplasia during Therapy*

摘要: ABSTRACT ABSTRACT. Serum 3α-androstanediol glucuronide (3α-diol G) measurements may indicate the extent of androgen metabolism and action in target tissues. To test this supposition we measured serum 3α-diol G concentrations 23 women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, including 13 salt-losing 10 simple virilizing form, while they were receiving glucocorticoid and, some cases, mineralocorticoid therapy. Their mean age was 28.3 yr (range, 17.9–38.7 yr). Twenty-four-hour urinary 17-ketosteroid excretion, plasma androstenedione testosterone levels, levels during follicular phase. The values within or below normal range 87%, 78%, 70%, 91% patients, respectively. By contrast, 17-hydroxyprogesterone only 12% patients. correlated well 24-h excretion (r = 0.75) 0.7...