Effect of androgen on adrenal steroidogenesis in normal women.

摘要: Ovarian hyperandrogenism may induce adrenal enzymatic defects that mimic true inherited disorders of hormone biosynthesis. To assess the effect on steroidogenesis, seven normal ovulatory women were studied 2 days during early follicular phase their cycles. Plasma 17-hydroxyprogesterone (17-Prog), 17-hydroxypregnenolone, dehydroepiandrosterone (DHEA), DHEA sulfate, androstenedione (Adione), testosterone (T), 11-deoxycortisol, and cortisol concentrations measured every 15 min for 3 h after iv injection 0.25 mg ACTH (day 1) pretreatment with dexamethasone each day. On second study day, T (80 micrograms/h) was infused 5 h, given infusion. The infusion raised mean serum levels from 1.2 +/- 0.3 (+/- SE) to 8.6 0.6 nmol/L. maximum incremental (delta max) plasma Adione response significantly higher (2.6 3.2 0.4 nmol/L; P less than 0.009) infusion, while delta max responses other steroids did not change. There an increase in 17-Prog ratio (4.9 0.7 7.0 1.0; 0.05), but no change or 17-hydroxypregnenolone ratios changes 5- 4-steroid ratios. These data suggest acute elevations result subtle inhibition 21-and/or 11 beta-hydroxylase activities, 17-20-desmolase beta-ol activities.