Influence of Individual Characteristics on Outcome of Glycemic Control in Intensive Care Unit Patients With or Without Diabetes Mellitus

摘要: OBJECTIVE To clarify the relationship of patient and critical illness characteristics (including any history diabetes mellitus) to glycemic control with insulin hospital mortality. PATIENTS AND METHODS A case-control descriptive study was performed patients admitted a tertiary-care center multi-disciplinary closed intensive care unit (ICU) at Mayo Clinic Hospital in Phoenix, Ariz, between January 1, 1999, December 31, 2003, after implementation management protocol. mortality, primary outcome, examined nondiabetic diabetic ICU receiving not requiring (control group). RESULTS Of 7285 patients, 2826 (39%) required insulin, 1083 whom (15% total) had mellitus. The group median (10th-90th percentile) glucose level 118 mg/dL (range, 97–153 mg/dL) 5% mortality rate. 134 110–181 170 (121–238 ( P .001). Compared survivors, nonsurvivors longer periods levels greater than 144 mg/dL. Diabetic vs survivors 200 Poor associated increased requirement Critical that predicted poor were advanced age, diabetes, cardiac surgery, postoperative complications, severity illness, nosocomial infections, prolonged mechanical ventilation, or concurrent medications. CONCLUSIONS determined clinical outcome patients. Acute resistance worse outcomes Although influenced control, future evaluation effect administration optimal is necessary.