Continuous insulin infusion is associated with a reduced post-surgical length of stay, but not with the complication rate, in patients with diabetes mellitus undergoing coronary artery bypass graft

作者: R. Tranbaugh , J. Schlosser , A. Busta , M. Bogun , S. Goldstein

DOI: 10.3275/7760

关键词: Complication rateGlycated hemoglobinInsulinSurgeryDiabetes mellitusInsulin infusionPost surgicalIn patientMedicineArtery

摘要: Objective: To establish if glucose management with continuous intravenous insulin infusion (CII) in the early post-operative period after coronary artery bypass graft (CABG) surgery is associated complication rate and length of hospital stay (LOS) patients diabetes mellitus (DM). Research design methods: We reviewed records 587 DM who underwent CABG from January 1999 until 2008; 316 were placed on CII, while 271 treated subcutaneous insulin. examined patient age, glycated hemoglobin (HgbA1c), 24- 72-h average capillary blood (CBG), (LOS), complications. Results: There was no difference HgbA1c between groups. Mean CBG values at both 24 h 72 remained same CII group (167 mg/dl), non-CII they 194 mg/dl 189 mg/dl, respectively (p<0.001 groups). Post-surgical median LOS 6 days 6.5 (p=0.003). Complications occurred similar (in 10% 11% patients) two Conclusions: a reduced post-surgical undergo CABG.

参考文章(52)
D G Altman, J M Bland, Quartiles, quintiles, centiles, and other quantiles BMJ. ,vol. 309, pp. 996- 996 ,(1994) , 10.1136/BMJ.309.6960.996
Alinejad B, Marzban M, Karimi A, Abbasi K, Shirzad M, Armadi Sh, Moshtaghi N, Effects of body mass index on early outcome of coronary artery bypass surgery. Minerva Chirurgica. ,vol. 64, pp. 17- 22 ,(2009)
A. Perner, S. E. Nielsen, J. Rask-Madsen, High glucose impairs superoxide production from isolated blood neutrophils. Intensive Care Medicine. ,vol. 29, pp. 642- 645 ,(2003) , 10.1007/S00134-002-1628-4
Guillermo E. Umpierrez, Scott D. Isaacs, Niloofar Bazargan, Xiangdong You, Leonard M. Thaler, Abbas E. Kitabchi, Hyperglycemia: An Independent Marker of In-Hospital Mortality in Patients with Undiagnosed Diabetes The Journal of Clinical Endocrinology and Metabolism. ,vol. 87, pp. 978- 982 ,(2002) , 10.1210/JCEM.87.3.8341
Ilse Vanhorebeek, Catherine Ingels, Greet Van den Berghe, Intensive insulin therapy in high-risk cardiac surgery patients: evidence from the Leuven randomized study. Seminars in Thoracic and Cardiovascular Surgery. ,vol. 18, pp. 309- 316 ,(2006) , 10.1053/J.SEMTCVS.2006.05.001
Justine M. Carr, Frank W. Sellke, Michelle Fey, Mathew J. Doyle, Judy A. Krempin, Ralph de la Torre, John R. Liddicoat, Implementing tight glucose control after coronary artery bypass surgery. The Annals of Thoracic Surgery. ,vol. 80, pp. 902- 909 ,(2005) , 10.1016/J.ATHORACSUR.2005.03.105
Greet Van den Berghe, Pieter Wouters, Frank Weekers, Charles Verwaest, Frans Bruyninckx, Miet Schetz, Dirk Vlasselaers, Patrick Ferdinande, Peter Lauwers, Roger Bouillon, Intensive Insulin Therapy in Critically Ill Patients The New England Journal of Medicine. ,vol. 345, pp. 1359- 1367 ,(2001) , 10.1056/NEJMOA011300
Yingxin Liu, Mike Phillips, Jim Codde, Factors influencing patients' length of stay. Australian Health Review. ,vol. 24, pp. 63- 70 ,(2001) , 10.1071/AH010063
Mohamed Y. Rady, Daniel J. Johnson, Bhavesh M. Patel, Joel S. Larson, Richard A. Helmers, Influence of Individual Characteristics on Outcome of Glycemic Control in Intensive Care Unit Patients With or Without Diabetes Mellitus Mayo Clinic Proceedings. ,vol. 80, pp. 1558- 1567 ,(2005) , 10.4065/80.12.1558