Vaccination against Helicobacter pylori in non-human primate models and humans.

摘要: Several vaccination studies have been performed in monkeys and humans testing the feasibility of prophylactic therapeutic immunizations against Helicobacter pylori. The monkey showed that immune responses were induced by oral with mucosal adjuvant LT (Escherichia coli heat-labile enterotoxin), parenteral administration a cationic lipid adjuvant, priming followed boosts. Both activities demonstrated monkeys, providing strong impetus for human vaccine trials. Preliminary undertaken order to identify tolerable dose or test effectiveness mutant atoxic adjuvants. results from these preliminary suggest native causes diarrhoea at doses required adjuvanticity while does not. In one study which infected subjects vaccinated orally administered urease antigen LT, there was modest reduction level H. pylori gastric colonization. A second clinical employing whole cell although remained infected, not designed measure Recombinant Salmonella expressing other antigens effective mice (see accompanying Frontlines Topic Review John O. Nedrud [1]), but are possible because host range restriction. Human trials immunization, immunization live vectors needed fully assess ability vaccines prevent treat infections.