Carbon Substrates: A Stable Foundation for Biomolecular Arrays.

摘要: Since their advent in the early 1990s, microarray technologies have developed into a powerful and ubiquitous platform for biomolecular analysis. Microarrays consist of three major elements: substrate upon which they are constructed, chemistry employed to attach biomolecules, biomolecules themselves. Although glass substrates silane-based attachment chemistries used vast majority current platforms, these materials suffer from severe limitations stability, due hydrolysis both material itself silyl ether linkages attachment. These stability compromise assay performance render impossible many potential applications. We describe here suite alternative carbon-based associated fabrication. The themselves, as well carbon-carbon bond-based chemistries, offer greatly increased chemical enabling m...