Dual Inhibition of Cathepsin G and Chymase Is Effective in Animal Models of Pulmonary Inflammation
作者： Bruce E. Maryanoff , Lawrence de Garavilla , Michael N. Greco , Barbara J. Haertlein , Grace I. Wells
DOI: 10.1164/RCCM.200904-0627OC
关键词:
摘要: Rationale: Mast cells and neutrophils are key contributors to the pathophysiological inflammatory processes that underpin asthma chronic obstructive pulmonary disease, partly through release of noxious serine proteases, including cathepsin G (Cat G) chymase. From this standpoint, a dual inhibitor neutrophil Cat mast cell chymase could protect against these disease-related responses.Objectives: We examined antiinflammatory pharmacology RWJ-355871, chymase, in animal models inflammation evince pathways relevant disease determine therapeutic potential compound.Methods: In an ovalbumin (OVA)-sensitized rat model, RWJ-355871 was administered block mast-cell–mediated increase paw volume caused by OVA injection. sheep antigen-induced airway responses were assessed with without aerosol treatment RWJ-355871. murine to...
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