PROSTACYCLIN (PGI2) INHIBITS THE FORMATION OF PLATELET THROMBI IN ARTERIOLES AND VENULES OF THE HAMSTER CHEEK POUCH
作者： E.A. HIGGS , G.A. HIGGS , S. MONCADA , J.R. VANE
DOI: 10.1111/J.1476-5381.1978.TB07809.X
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摘要: 1 Isolated rings of hamster aorta produced an unstable substance which inhibited platelet aggregation in vitro and had the same characteristics as prostacyclin. 2 Prostacyclin adenosine diphosphate (ADP)-induced platelets vitro. 3 The effects prostacyclin on ADP-induced thrombi microcirculation cheek pouch were studied with a television microscope. 4 Prostacyclin caused dose-dependent increase time iontophoretic application ADP was required to induce formation embolization venules (30 40 μm diameter). 5 Prostacyclin reduction total during observed following local electrical damage arterioles (40 80 diameter). 6 Thrombus abolished by 500 ng/ml Krebs solution superfusing pouch. 7 Prostacyclin approximately twenty times more potent than prostaglandin E1 preventing thrombus microcirculation.
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