Uptake and degradation of rat and human very low density (remnant) apolipoprotein by parenchymal and non-parenchymal rat liver cells.
作者： Arie van Tol , Theo J.C. van Berkel
DOI: 10.1016/0005-2760(80)90251-9
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摘要: Abstract 1. The relative contribution of parenchymal and non-parenchymal cells to the in vivo hepatic uptake serum apolipoproteins was measured 30 min after intravenous injection radioiodinated rat very low density lipoprotein (VLDL) remnants, human VLDL, (LDL) high (HDL). Using VLDL-remnants, LDL HDL, respectively, contain 4.7, 4.9, 6.1 5.3 times amount trichloroacetic acid-precipitable radioactivity per mg cell protein as compared cells. For HDL these values are 5.1, 12.0 5.9, respectively. 2. abilities homogenates liver, liver hydrolyze iodinated VLDL apoprotein were determined by measuring acid-soluble (non-iodide) liberated upon incubation at optimal pH 4.2. Non-parenchymal possess a 8–21-fold higher maximal capacity degrade than This factor is 5–6 for VLDL-remnant degradation (suboptimal) apolipoprotein concentrations. 3. It concluded that, addition cells, play an important role possibly VLDL-(remnant) apoprotein.
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