Interactions of endogenous lipoproteins with capillary endothelium in spontaneously hyperlipoproteinemic rats
作者： Nicolae Simionescu , Maya Simionescu
DOI: 10.1016/0026-2862(85)90063-9
关键词:
摘要: Abstract In spontaneously hyperlipoproteinemic old Sprague-Dawley rats, endogenous lipoproteins (LP) in the size range of 15 to 40 nm were directly visualized within blood vessels due specimen mordanting with tannic acid. LP morphometric analysis at level endothelium diaphragm capillaries revealed that particles dimensions low-density lipoproteins, high-density (HDL1), and very low density occur endothelial structures involved receptor-mediated endocytosis (coated pitsvesicles, endosomes, lysosomes) transcytosis (plasmalemmal vesicles transendothelial channels). No such could be detected intercellular junctions. Intravenously injected cationized ferritin (CF) pI 8.4 bound uniformly forming an CF-LP complex. Examined 5, 20, 60 min after CF administration, complex was found taken up by only (adsorptive via coated fluid phase through a fraction plasmalemmal vesicles). complexes are progressively accumulated lysosomes. These findings reveal importance net surface charge macromolecular for their intracellular sorting fate.
elsevier.com
sci-hub.se 参考文章(54)
German Camejo, Interaction of Low Density Lipoproteins with Arterial Constituents: Its Relationship with Atherogenesis Springer, Boston, MA. pp. 351- 369 ,(1976) , 10.1007/978-1-4684-2250-4_13
Arie van Tol, Theo J.C. van Berkel, Uptake and degradation of rat and human very low density (remnant) apolipoprotein by parenchymal and non-parenchymal rat liver cells. Biochimica et Biophysica Acta. ,vol. 619, pp. 156- 166 ,(1980) , 10.1016/0005-2760(80)90251-9
N. Simionescu, Transcytosis and Traffic of Membranes in the Endothelial Cell International Cell Biology 1980–1981. pp. 657- 672 ,(1981) , 10.1007/978-3-662-39932-3_73
T. L. Innerarity, R. W. Mahley, D. L. Fry, K. H. Weisgraber, Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro. American Journal of Pathology. ,vol. 87, pp. 205- 226 ,(1977)
Santibrata Ghosh, Interaction of Low Density Lipoproteins with Small and Large Molecules Springer, Boston, MA. pp. 371- 419 ,(1976) , 10.1007/978-1-4684-2250-4_14
Simon J.T. Mao, Raymond E. Kazmar, Joel C. Silverfield, Michael C. Alley, Kathryn Kluge, C.Garrison Fathman, Immunochemical properties of human low density lipoproteins as explored by monoclonal antibodies. Binding characteristics distinct from those of conventional serum antibodies. Biochimica et Biophysica Acta. ,vol. 713, pp. 365- 374 ,(1982) , 10.1016/0005-2760(82)90255-7
Simeon Margolis, Robert G. Langdon, Studies on Human Serum β1-Lipoprotein I. AMINO ACID COMPOSITION Journal of Biological Chemistry. ,vol. 241, pp. 469- 476 ,(1966) , 10.1016/S0021-9258(18)96941-3
A.B. Gilbert, M.M. Perry, Yolk transport in the ovarian follicle of the hen (Gallus domesticus): lipoprotein-like particles at the periphery of the oocyte in the rapid growth phase Journal of Cell Science. ,vol. 39, pp. 257- 272 ,(1979) , 10.1242/JCS.39.1.257
Shunichi Koga, David L. Horwitz, Angelo M. Scanu, Isolation and properties of lipoproteins from normal rat serum. Journal of Lipid Research. ,vol. 10, pp. 577- 588 ,(1969) , 10.1016/S0022-2275(20)43052-4
Norman L. Lasser, Paul S. Roheim, Diane Edelstein, Howard A. Eder, Serum lipoproteins of normal and cholesterol-fed rats. Journal of Lipid Research. ,vol. 14, pp. 1- 8 ,(1973) , 10.1016/S0022-2275(20)39322-6