A highly enantioselective synthesis of (R)- and (S)-5,7-odimethyleucomol
作者： Franklin A. Davis , Bang-Chi Chen
DOI: 10.1016/S0040-4039(00)97181-8
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摘要: Abstract Both (R)- and (S)-5,7-O-dimethyleucomol 1b (R = Me) were synthesized in 57% overall yield >96% enantiomeric excess. The key step involves the enantioselective α hydroxylation of lithium enolate 8 by readily available (+)- (−)-[(8,8-dimethoxycamphoryl)sulfonyl]oxaziridine 9c .
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