ROCK1, a novel target of miR-145, promotes glioma cell invasion.
作者： ZIGUI CHEN , YIQIANG CAO , BING JIANG , XIN WAN , QUAN CHENG
关键词:
摘要: Malignant glioma is the most common type of cancer in central nervous system, with highly invasive characteristics. The Rho-associated protein kinase (ROCK1) has been found to act as key regulator actin cytoskeleton reorganization, a process closely associated cell invasion. microRNA-145 (miRNA-145) recently shown suppressor several types tumor, including glioma. However, exact regulatory mechanism by which miR-145 inhibits still remains be uncovered. In this study, we report that level was significantly reduced tissues and human lines U87 U251, compared matched adjacent normal brain tissues. We then identified ROCK1 gene novel target miR-145. expression markedly upregulated tissues, well U251 cells. Moreover, inhibited further show transfection considerably ability cells, accompanied downregulation matrix metalloproteinase 2 9, an effect could attenuated overexpression ROCK1. conclusion, present study suggests can inhibit invasion, at least partially via RhoA/ROCK1 pathway. first ROCK1, miR-145, acts positive Therefore, may constitute promising for treatment.
spandidos.org参考文章(31)
Aneta Kwiatkowska, Marc Symons, Signaling Determinants of Glioma Cell Invasion Advances in Experimental Medicine and Biology. ,vol. 986, pp. 121- 141 ,(2013) , 10.1007/978-94-007-4719-7_7
Mitsutoshi Nakada, Daisuke Kita, Lei Teng, Ilya V. Pyko, Takuya Watanabe, Yutaka Hayashi, Jun-ichiro Hamada, Receptor Tyrosine Kinases: Principles and Functions in Glioma Invasion Advances in Experimental Medicine and Biology. ,vol. 986, pp. 143- 170 ,(2013) , 10.1007/978-94-007-4719-7_8
Maria Carmela Speranza, Véronique Frattini, Federica Pisati, Dimos Kapetis, Paola Porrati, Marica Eoli, Serena Pellegatta, Gaetano Finocchiaro, NEDD9, a novel target of miR-145, increases the invasiveness of glioblastoma Oncotarget. ,vol. 3, pp. 723- 734 ,(2012) , 10.18632/ONCOTARGET.547
Simeng Wen, Zhiqun Shang, Shimiao Zhu, Chawnshang Chang, Yuanjie Niu, Androgen receptor enhances entosis, a non-apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells The Prostate. ,vol. 73, pp. 1306- 1315 ,(2013) , 10.1002/PROS.22676
Patrick Oellers, Uwe Schröer, Volker Senner, Werner Paulus, Solon Thanos, ROCKs are expressed in brain tumors and are required for glioma-cell migration on myelinated axons. Glia. ,vol. 57, pp. 499- 509 ,(2009) , 10.1002/GLIA.20777
Takeshi Chiyomaru, Shuichi Tatarano, Kazumori Kawakami, Hideki Enokida, Hirofumi Yoshino, Nijiro Nohata, Miki Fuse, Naohiko Seki, Masayuki Nakagawa, SWAP70, actin-binding protein, function as an oncogene targeting tumor-suppressive miR-145 in prostate cancer† The Prostate. ,vol. 71, pp. 1559- 1567 ,(2011) , 10.1002/PROS.21372
Marie Morgan-Fisher, Ulla M. Wewer, Atsuko Yoneda, Regulation of ROCK Activity in Cancer Journal of Histochemistry and Cytochemistry. ,vol. 61, pp. 185- 198 ,(2013) , 10.1369/0022155412470834
Yongzhi Wang, Tao Jiang, Understanding high grade glioma: Molecular mechanism, therapy and comprehensive management Cancer Letters. ,vol. 331, pp. 139- 146 ,(2013) , 10.1016/J.CANLET.2012.12.024
Ruey-Hwa Chen, Won-Jing Wang, Jean-Cheng Kuo, The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulation Journal of Biomedical Science. ,vol. 13, pp. 193- 199 ,(2006) , 10.1007/S11373-005-9063-5
Zohreh Tabatabai, Rajvir Dahiya, S Majid, AA Dar, S Saini, V Shahryari, S Arora, MS Zaman, I Chang, S Yamamura, T Chiyomaru, S Fukuhara, None, MicroRNA-1280 Inhibits Invasion and Metastasis by Targeting ROCK1 in Bladder Cancer PLoS ONE. ,vol. 7, pp. e46743- ,(2012) , 10.1371/JOURNAL.PONE.0046743