The Doublesex Homolog Dmrt5 is Required for the Development of the Caudomedial Cerebral Cortex in Mammals

摘要: Regional patterning of the cerebral cortex is initiated by morphogens secreted centers that establish graded expression transcription factors within cortical progenitors. Here, we show Dmrt5 expressed in progenitors a high-caudomedial to low-rostrolateral gradient. In its absence, strongly reduced and exhibits severe abnormalities, including agenesis hippocampus choroid plexus defects commissural thalamocortical tracts. Loss results decreased Wnt Bmp one major telencephalic centers, dorsomedial telencephalon, reduction Cajal-Retzius cells. Expression dorsal midline signaling center-dependent downregulated, Emx2, which promotes caudomedial fates, while rostral determinant Pax6, inhibited signals, upregulated. Consistently, Dmrt5(-/-) brains exhibit with dramatic cortex. increased upon activation downregulated Gli3(xt/xt) mutants. We conclude novel Wnt-dependent factor required for early development it may regulate initial promoting center formation thereby helping other regulators identity.