Principles and Procedures of Human Immunodeficiency Virus Serodiagnosis

摘要: An important early impetus for the development and testing of serologic methods to detect human immunodeficiency virus (HIV) infection was need guarantee safety blood supply. A quick review statistics provided in this chapter makes clear continued methods, including point-of-care testing, that are useful especially resource-poor settings. The standard screening tests HIV involve detection HIV-specific antibodies. enzyme-linked immunosorbent assay (ELISA) is test HIV-1 infection. Individuals with indeterminate or positive ELISA results should undergo confirmation (generally by Western blotting [immunoblotting]) determine if reactivity primarily directed secondarily cross-reacting It has now become practice banks screen donated samples one new HIV-1-HIV-2 combination ELISAs. major core protein p24. p24 antigen been used many years prognostic staging management infected individuals licensed United States as part routine donor screening. Serologic assays antibodies most widely means laboratory diagnosis Most algorithms include an component confirmatory method.