Progression and regression of premalignant cervical lesions in HIV-infected women from Soweto: a prospective cohort.

作者: Tanvier Omar , Sheree Schwartz , Colleen Hanrahan , Tebogo Modisenyane , Nkeko Tshabangu

DOI: 10.1097/QAD.0B013E328340FD99

关键词:

摘要: Objective: To ascertain progression and regression of cervical dysplasia in HIV-infected women Soweto. Design: Prospective cohort. Methods: Women attending an HIV wellness clinic were offered smears as part care; assessed using the Bethesda system. Those with high-grade lesions or worse referred for colposcopy. Progression analyses included at least two 5.5 months apart. Hazard ratios used to predictors progression. Results: Two thousand, three hundred twenty-five had a baseline smear; their median age CD4 cell count was 32 years 312 cells/μl, respectively; 17% taking highly active antiretroviral therapy (HAART); 62, 20 14% normal, low-grade squamous intraepithelial (LSIL) (HSIL), respectively. Of those normal LSIL smears, 1074 another from 9.6/100 person-years (95% CI 8.3-11.1) HSIL 4.6/100 3.9-5.5). 225 one subsequent smear 11.5 later, 44.0% regressed (21.2/100 17.5-25.7)). Multivariate models suggested increasing risk below 500cells/μl HAART may reduce [adjusted hazard ratio (aHR) 0.72 (0.52-0.99)]. Conclusion: have high rates prevalent incident relatively low LSIL. appears protect against Our findings suggest screening intervals should be less than 10 - irrespective counts 500 cells/μl.

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