Extraction of amphetamines and methylenedioxyamphetamines from urine using a monolithic silica disk-packed spin column and high-performance liquid chromatography-diode array detection.
作者： Akira Namera , Akihiro Nakamoto , Manami Nishida , Takeshi Saito , Izumi Kishiyama
DOI: 10.1016/J.CHROMA.2008.08.091
关键词:
摘要: To overcome the limitations of solid-phase extraction, we developed a device comprising spin column packed with octadecyl silane-bonded monolithic silica for extracting amphetamines and methylenedioxyamphetamines from urine. Urine (0.5mL), buffer (0.4mL), methoxyphenamine (internal standard) were directly put into preactivated column. The was centrifuged (3000rpm, 5min) sample loading washed. adsorbed analytes eluted analyzed by high-performance liquid chromatography, without evaporation. results as follows: linear curves (drug concentrations 0.2-20microg/mL); correlation coefficients >0.99; detection limit, 0.1microg/mL. proposed method is not only useful drugs biological materials but also highly reproducible analysis these in
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