Fetal exposure to PCBs and their hydroxylated metabolites in a Dutch cohort.

摘要: Polychlorinated biphenyls (PCBs) are still the most abundant pollutants in wildlife and humans. Hydroxylated PCB metabolites (OH-PCBs) known to be formed humans wildlife. Studies animals show that these cause endocrine-related toxicity. The health effects have not yet been evaluated, especially effect on fetus newborn. aim of this study is measure levels PCBs OH-PCBs maternal cord blood samples a population with background PCBs. We analyzed 51 corresponding northern part Netherlands. concentrations plasma ranged from 2 293 ng/g lipid, OH-PCB nondetectable (ND) 0.62 fresh weight. In plasma, were 1–277 concentrations, ND 0.47 versus calculated ratio was 1.28 ± 0.56 for 2.11 1.33 OH-PCBs, expressed per gram lipid. When weight, ratios 0.32 0.15 0.53 0.23 respectively. A significant correlation between respective both found. Our results indicate transferred across placenta resulting approximately 50 30%, respectively, those plasma. More research needed evaluate potential negative endocrine disruptors fetus.