Annona squamosa seed extract in the regulation of hyperthyroidism and lipid-peroxidation in mice: possible involvement of quercetin.

作者: S. Panda , A. Kar

DOI: 10.1016/J.PHYMED.2006.12.001

关键词:

摘要: Annona squamosa (Custard apple) seeds are generally thrown away as waste materials. The extract of these was evaluated for its possible ameliorative effect in the regulation hyperthyroidism mouse model. Serum triiodothyronine (T(3)), thyroxine (T(4)) concentrations, hepatic glucose-6-phospatase (G-6-Pase) and 5'-mono-deiodinase (5'DI) activity were considered end parameters thyroid function. Simultaneously lipid peroxidation (LPO), superoxide dismutase (SOD) catalase (CAT) activities investigated to observe hepatotoxic effect, if any. L-T(4) administration (0.5 mg/kg/d 12 days, i.p.) increased levels serum T(3) T(4), G-6-Pase, 5'DI LPO with a parallel decrease SOD CAT activities. However, simultaneous seed (200 mg/kg) or quercetin (10 T(4)-induced hyperthyroid animals 10 reversed all effects indicating their potential hyperthyroidism. Further, did not increase, but decreased suggesting safe antiperoxidative nature. Quercetin also LPO. When relative efficacy compared that propyl thiouracil (PTU), standard antithyroidic drug, experimental appeared be more effective. Phytochemical analyses including HPLC revealed presence results on suggested involvement this phytochemical mediation antithyroidal extract.

参考文章(19)
Barry Halliwell, John M. C. Gutteridge, Free radicals in biology and medicine ,(1985)
S. Panda, A. Kar, Regulation of Hyperthyroidism by Rauwolfia serpentina Root Extract in Mice Pharmacy and Pharmacology Communications. ,vol. 6, pp. 517- 520 ,(2000) , 10.1211/146080800128735629
Faith B Davis, Elliott Middleton, Paul J Davis, Susan D Blas, Inhibition by quercetin of thyroid hormone stimulation in vitro of human red blood cell Ca2+-ATPase activity Cell Calcium. ,vol. 4, pp. 71- 81 ,(1983) , 10.1016/0143-4160(83)90036-2
Sidney H. Ingbar, The Thyroid Gland. Archives of Internal Medicine. ,vol. 116, pp. 956- 957 ,(1965) , 10.1001/ARCHINTE.1965.03870060154035
Fang-Rong Chang, Chih-Chuang Liaw, Chih-Yuan Lin, Chi-Jung Chou, Hui-Fen Chiu, Yang-Chang Wu, New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata. Planta Medica. ,vol. 69, pp. 241- 246 ,(2003) , 10.1055/S-2003-38485
Rao L. Divi, Daniel R. Doerge, Inhibition of thyroid peroxidase by dietary flavonoids. Chemical Research in Toxicology. ,vol. 9, pp. 16- 23 ,(1996) , 10.1021/TX950076M
D.C. Damasceno, G.T. Volpato, T.C.F. Sartori, P.F. Rodrigues, E.A. Perin, I.M.P. Calderon, M.V.C. Rudge, Effects of Annona squamosa extract on early pregnancy in rats Phytomedicine. ,vol. 9, pp. 667- 672 ,(2002) , 10.1078/094471102321616508
SUNANDA PANDA, PANKAJ TAHILIANI, ANAND KAR, Inhibition of triiodothyronine production by fenugreek seed extract in mice and rats. Pharmacological Research. ,vol. 40, pp. 405- 409 ,(1999) , 10.1006/PHRS.1999.0510