A Deformable High Resolution Anatomic Reference for Pet Activation Studies

摘要: Presently available anatomic atlases provide useful coordinate systems such as the ubiquitous Talairach system but are sorely lacking in both spatial resolution and completeness. An appropriately sampled specimen can additional detail necessary to accurately localize activation sites well other structural perspectives chemoarchitecture. As part of International Consortium for Brain Mapping (ICBM), whose goal it is develop a probabilistic reference human brain, we collected serial section postmortem data from several whole head brain specimens using cryosectioning technique. Tissue imaged so that voxel was 200 microns or better at full color (24 bits/pixel. The sets were used one ways an functional studies. First, on individual basis traditional, n=1 atlas with unprecedented complete coverage forebrain, midbrain hindbrain. dataset be registered either landmarks automatic approach. Second, these high datasets placed within produce representation. This approach represents anatomy probability. Coordinate locations assigned confidence limit describe likelihood given location belongs structure based upon population specimens. These digital, densitometric resolution, 3D, comprehensive and, combination, probabilistic. superior makes possible delineate structures impossible visualize modalities. important analyses focus mapping brain.