Magnetic Resonance Imaging of Human Intracortical Structure in vivo

摘要: Current neuroimaging methodologies have lacked the resolution needed to visualize cortical organization at microscopic level. As a consequence, when neurological diseases disrupt internal structure of cerebral cortex, changes can only be visualized postmortem, by histological examination. This imposes severe limitations in vivo diagnosis and investigation those conditions. Here, we report on magnetic resonance technique that permitted visualization some features cortex 14 living human subjects 2 fixed brains. The key finding was periodic pattern low- high-signal slabs, oriented perpendicularly pial surface, seem correspond, respectively, columnar modules myelin septa. parameters new protocol included modifications pulse sequence, field view, number repetitions, plane sectioning.