Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage.

摘要: BACKGROUND: Treating hemorrhage with blood transfusions in subjects previously hemodiluted different colloidal plasma expanders, using fresh autologous or that has been stored for 2 weeks, allows identifying the interaction between type of expander and differences storage. STUDY DESIGN AND METHODS: Studies used hamster window chamber model. Fresh plasma, 130-kDa starch-based (hydroxyethyl starch [HES]), 4% polyethylene glycol–conjugated albumin (PEG-Alb) was 20% volume (BV) hemodilution. Hemodilution followed by a 55% BV 40-minute hemorrhagic shock period, treated transfusion 2 weeks. Outcome evaluated 1 hour after terms microvascular systemic variables. RESULTS: Results were principally dependent on solution during hemodilution, PEG-Alb yielding best recovery functional capillary density. This result consistent whether treating subsequent period. results significantly better relative to blood. HES hemodilution yielded less favorable results, difference enhanced when versus compared their efficacy correcting hemorrhage. CONCLUSION: The influences short-term outcome resuscitation transfusion, providing most comparison plasma.