Systemic and subcutaneous microvascular Po2 dissociation during 4-h hemorrhagic shock in conscious hamsters

摘要: The relationship between systemic and microvascular Po2 in subcutaneous connective tissue hemodynamics was investigated during 4-h hemorrhagic shock (40 mmHg) conscious Syrian hamsters (n = 66) fitted with a dorsal skinfold window. Systemic blood gases, metabolic parameters, arteriolar, venular, Po2, red cell velocity, flow were evaluated survivors (S) nonsurvivors (NS). Surviving animals resuscitated shed blood. Microvascular measured by phosphorescence decay of Pd-meso-tetra (4-carboxyphenyl) porphyrin (30 mg/kg body wt iv). Shock caused significant dissociation arterial arteriolar levels. Arterial increased from 59.7 +/- 12.0 to 110.8 19.7 mmHg 64.0 13.7 128.5 10.1 (NS), whereas large arterioles decreased 56.9 5.5 (control) 29.5 20.1 6.0 5.7 Correspondingly, fell 24.1 6.8 0.9 0.6 0.4 0.3 Venous 28.8 3.7 20.4 4.1 28.0 2.9 16.3 0.5 outcome oxygenation predicted gases microcirculatory conditions but not central venous Po2.