Synthesis and antimicrobial potential of nitrofuran–triazole congeners

摘要: A series of 5-nitrofuran-triazole congeners were designed and synthesized by carrying out suitable structural modifications the previously reported counterparts evaluated for their antimicrobial potential against both Gram-positive Gram-negative bacterial strains. The compounds exhibited promising inhibition towards different pathogenic strains, while mild inhibitory effects observed Some 9f, 9g, 9l 9m most active among series, exhibiting a MIC value 1.9 μg mL(-1) bactericidal activity was found to be in coherence with growth data. tested fourteen fungal strains possess excellent antifungal activities. Interestingly, all equipotent miconazole one or more showed good other counterparts. similar trend case minimum fungicidal concentration values. Moreover, compound 9f two fold superior (MIC = 3.9 mL(-1)) than standard 7.8 C. albicans parapsilosis. These also effectively inhibited biofilm formation anti-biofilm demonstrating (BIC) as low 0.8 mL(-1). brief mechanistic study carried on effective conjugate indicated that it inhibits ergosterol biosynthesis, thereby effects. Molecular modelling studies binding modes correlates well supported biosynthesis assay Most these ten times lower cytotoxicity toward normal cells compared activity.