Genetic Determinants in HLA and Cytochrome P450 Genes in the Risk of Aromatic Antiepileptic-Induced Severe Cutaneous Adverse Reactions.
作者： Chonlaphat Sukasem , Nur Aizati Athirah Daud , Dzul Azri Mohamed Noor , Ali Fadhel Ahmed , Nur Fadhlina Musa
DOI: 10.3390/JPM11050383
关键词:
摘要: Adverse drug reaction (ADR) is a pressing health problem, and one of the main reasons for treatment failure with antiepileptic drugs. This has become apparent in event severe cutaneous adverse reactions (SCARs), which can be life-threatening. In this review, four hypotheses were identified to describe how immune system triggered development SCARs, predominantly involve human leukocyte antigen (HLA) proteins. Several genetic variations HLA genes have been shown strongly associated susceptibility developing SCARs when prescribed carbamazepine or phenytoin. These also prevalent certain populations. Apart from genes, other proposed affect risk are encoding CYP450 drug-metabolising enzymes, involved pharmacokinetics offending Genetic variants CYP2C9 CYPC19 enzymes suggested modulate some review summarizes literature on manifestation aetiology antiepileptic-induced updates pharmacogenetic markers implementation pre-emptive testing as preventive strategy SCARs.
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