Evaluation of the drug-induced lymphocyte stimulation test for diagnosing mesalazine allergy

摘要: Background/aims Mesalazine is an effective drug for treating ulcerative colitis (UC), but causes allergic symptoms in a few cases. Therefore, the objective of this study was to evaluate usefulness drug-induced lymphocyte stimulation test (DLST) diagnosis mesalazine allergy. Methods Patients with UC treated or without history associated adverse events (AEs) were enrolled at Kyorin University Hospital from July 2016 April 2017. Results The DLST performed 104 patients UC, which 24 had AEs due treatment. control value 337.4±296.3 counts per minute (cpm) AE+ group and 408.0±371.9 cpm AE- group. measured 578.8±424.7 476.5±471.8 index (SI) 243.9%±291.1% 119.8%±53.0% SI positivity significantly higher than (P=0.030 P=0.029, respectively). sensitivity specificity 0.240 0.805, respectively, false-positive false-negative rate 0.195 0.760, respectively. Conclusions showed low high specificity, suggesting that it may be useful definitive allergy mesalazine.