Distinct Thresholds for CD8 T Cell Activation Lead to Functional Heterogeneity: CD8 T Cell Priming Can Occur Independently of Cell Division

摘要: To examine the bases for CD8 T cell functional heterogeneity, we analyzed responses to partial vs full agonist Ag. An extended period of interaction with APCs was required set threshold division in response as compared Acquisition cytolytic function restricted divided population. In contrast, commitment produce IFN-γ and express some activation markers appeared lower independent division. Indeed, characterized a population stimulated that committed IFN-γ, but failed divide or secrete IL-2. Importantly, this activated nondivided behaved “primed” rather than “anergized,” indicating 1) priming cells may be induced by suboptimal stimulation 2) encounter Ag does not always induce complete differentiation program naive cells, previously reported.