Early Plasmodium-induced inflammation does not accelerate aging in mice.

摘要: Aging is associated with a decline of performance leading to reduced reproductive output and survival. While the antagonistic pleiotropy theory aging has attracted considerable attention, molecular/physiological functions underlying early-life benefits/late-life costs paradigm remain elusive. We tested hypothesis that while early activation inflammatory response confers benefits in terms protection against infection, it also incurs at old age shortened longevity. infected mice malaria parasite Plasmodium yoelii increased using an anti-IL-10 receptor antibody treatment. quantified during acute phase infection age. In agreement hypothesis, provided benefit, since were treated antibodies had density anemia. However, age, all treatment groups similar levels C-reactive protein, output, survival rate, lifespan. Overall, our results do not support robust life incur longer term fitness costs.