Origin and recent expansion of an endogenous gammaretroviral lineage in canids

摘要: Mammalian genomes contain a fossilized record of ancient retroviral infections in the form endogenous retroviruses (ERVs). We used whole genome sequence data to assess origin and evolution recently active ERV-Fc gammaretroviral lineage based on past retained domestic dog, Canis lupus familiaris. identified 165 loci, including 58 insertions absent from dog reference assembly, characterized element polymorphism across 332 canids nine species. Insertions were found throughout within near gene models. Analysis 19 proviral sequences shared disruptive mutations indicating defective proviruses spread via complementation. The patterns ERV variation indicate multiple circulating viruses infected canid ancestors last 20 million 1.6 years with recent bust germline invasion leading wolves dogs.