Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs
作者： Adam Auton , Ying Rui Li , Jeffrey Kidd , Kyle Oliveira , Julie Nadel
DOI: 10.1371/JOURNAL.PGEN.1003984
关键词:
摘要: The identification of the H3K4 trimethylase, PRDM9, as gene responsible for recombination hotspot localization has provided considerable insight into mechanisms by which is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version PRDM9 and may therefore provide model understanding that occurs absence thus how functions shape landscape. We have constructed fine-scale genetic map from patterns linkage disequilibrium assessed using high-throughput sequence data 51 free-ranging dogs, Canis lupus familiaris. While broad-scale properties similar other mammalian species, our estimates indicate canine highly elevated rates are observed vicinity CpG rich regions including promoter regions, but show little association with trimethylation marks identified spermatocytes. By comparison genomic Andean fox, Lycalopex culpaeus, we biased conversion plausible mechanism high content dog genome could occurred.
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