Genetic structure in village dogs reveals a Central Asian domestication origin.

摘要: Dogs were the first domesticated species, originating at least 15,000 y ago from Eurasian gray wolves. today consist primarily of two specialized groups—a diverse set nearly 400 pure breeds and a far more populous group free-ranging animals adapted to human commensal lifestyle (village dogs). Village dogs are genetically geographically widespread than purebred making them vital for unraveling dog population history. Using semicustom 185,805-marker genotyping array, we conducted large-scale survey autosomal, mitochondrial, Y chromosome diversity in 4,676 161 549 village 38 countries. Geographic structure shows both isolation gene flow have shaped genetic populations. Some populations (notably those Neotropics South Pacific) almost completely derived European stock, whereas others clearly admixed between indigenous dogs. Importantly, many populations—including Vietnam, India, Egypt—show minimal evidence admixture. These exhibit clear gradient short-range linkage disequilibrium consistent with Central Asian domestication origin.