Roles of Cyclooxygenase-2 gene -765G > C (rs20417) and -1195G > A (rs689466) polymorphisms in gastric cancer: A systematic review and meta-analysis.

摘要: Abstract Background The roles of cyclooxygenase-2 (COX2) −765G > C (rs20417) and −1195G > A (rs689466) polymorphisms in gastric cancer were intensively analyzed, but the results these studies inconsistent. We conducted a meta-analysis trial sequential analysis to elucidate associations between two COX2 risk. Methods Eligible searched PubMed, Embase, Cochrane library databases, China National Knowledge Infrastructure, Vip, Wanfang databases. Odds ratios (ORs) with 95% confidence intervals (CIs) used assess genetic correlation susceptibility five models. Trial (TSA) was estimate whether evidence is sufficient. Furthermore, their interactions Helicobacter pylori (H. pylori) or smoking also assessed using case-only method. Results gene polymorphism showed no significant association under all models (take allelic model for example: OR = 1.41, CI: 0.95–2.09) total analysis, stratification by ethnicity indicated similar Caucasian group four (allelic model, dominant homozygous heterozygous model). But subgroup Asian population, significantly associated risk same contrast. revealed both groups Moreover, TSA confirmed such associations. Both H. infection cigarette interacted -765 C allele (OR = 3.79, 1.15–12.43 OR = 2.48, 1.38–4.48, respectively), not −1195 A (OR = 1.96, 0.62–6.21, OR = 1.24, 0.93–1.64, respectively). Conclusions may serve as biomarker Asians, Caucasians. Asians −765G > C, rather than increase