Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages.

摘要: We compared the impact of IL-4 and IL-5 deficiency during fully permissive infection BALB/c mice with rodent filaria Litomosoides sigmodontis. IL-5, in contrast to IL-4, is crucial for containment adult worms short- long-term infections. KO allowed development more larvae into showed up 200 times persisting chronic (day 60 until post-infection). This increased persistence was accompanied by a reduction inflammatory nodules around filariae. In contrast, worm survival nodule formation did not differ between wild-type or receptor (IL-4R) α-chain mice. both microfilaraemia greatly enhanced (160-fold) prolonged extent susceptibility microfilariae required presence full cycle since upon intraperitoneal injection alone they were removed from BALB/c, IL-4R equivalent kinetics, microfilarial only slightly (factor 5 vs. factor 160 infection). conclusion, dependent effector pathways operate against different stages filarial worms, has greater on parasite than IL-4.