Regulation of G-Protein Coupled Receptor Cytosolic mRNA Binding Proteins

摘要: The regulation of G-protein coupled receptor (GPCR) expression is an area intense interest because GPCRs play a crucial role in many key physiological and pathological processes. Indeed, greater than 60% all pharmaceuticals are targeted towards GPCRs. ability to regulate GPCR protein at the post-transcriptional level provides mechanism past transcriptional regulatory point when genes turned on or off. This allows finer control for that critically involved myriad critical cell functions such as growth, differentiation, development. In majority instances regulation, binding specific proteins defined sequences and/or structures target mRNA, governs splicing, nucleocytoplasmic transport, subcellular localization, translation mRNA degradation. this chapter, we focus via cytosolic RNA that, through interaction with contribute determining by altering rate its stability. Highlighted our studies interact 5’ leader sequence angiotensin AT1 receptor, blood pressure fluid homeostasis.