Neural oscillations in the infralimbic cortex after electrical stimulation of the amygdala. Relevance to acute stress processing.

摘要: The stress system coordinates the adaptive reactions of organism to stressors. Therefore, dysfunctions in this circuit may correlate anxiety-related disorders, including depression. Comprehending dynamics network lead a better understanding mechanisms that underlie these diseases. central nucleus amygdala (CeA) activates hypothalamic-pituitary-adrenal axis and brainstem nodes by triggering endocrine, autonomic behavioral responses. medial prefrontal cortex plays significant role regulating stressors, is specifically important for limiting fear Brain oscillations reflect neural systems activity. Synchronous neuronal assemblies facilitate communication synaptic plasticity, cooperatively support temporal representation long-term consolidation information. purpose article was delve into interactions between structures contexts evaluating changes oscillatory We particularly analyzed local field potential infralimbic region (IL) urethane-anesthetized rats after electrical activation mimicking firing rates induced acute stress. Electrical CeA delayed, but significant, change IL, with prominent slow waves accompanied an increase theta gamma activities, spindles. phase-amplitude coupling both significantly increased faster oscillations, theta-gamma nesting spindles, wave cycle. These results are further discussed processing terms response memory formation.