HEPATOCELLULAR CANCER: A Century of Progress

摘要: At the beginning of twentieth century, hepatocellular cancer (HCC) was thought to be uncommon, and almost nothing known its origin or pathogenesis. end HCC is considered one major malignant diseases worldwide, principal risk factors have been identified, a start has made in unravelling complex processes involved pathogenesis prevention. Despite this progress, results treatment symptomatic are as disappointing today, prognosis grave, at turn century. Consequently, prevention must priority. Although global importance now beyond doubt, validity earlier belief that tumor uncommon may questioned. first-world countries century and, indeed, remains so most them, it uncertain what incidence time those Third World eastern south-eastern Asia, western Pacific islands, subSaharan Africa, where today prevalent among tumors. The causal association chronic hepatitis B virus (HBV) infection. Hepatitis viruses spread predominantly by fecal oral route responsible for epidemics jaundice long ago Middle Ages. transmitted parenterally already before possibly result practice ritual therapeutic scarification transmission blood-sucking vectors. not documented, would then common time. In contrast, HBV infection emerged public health problem First more recently, following introduction blood transfusion, widespread use parenteral therapy, emergence large-scale intravenous drug abuse, liberalization sexual practices. will progress lower these countries.