Simple Fabrication of Glutathione-Responsive PEGylated Micellar Nanocarriers for Dual Drugs Delivery
作者： Shuling Zhao , Dongdong Wang , Kelin Zhang , Haixia Zhang
DOI: 10.1080/00914037.2015.1030649
关键词:
摘要: The authors report a feasible simple method to fabricate two kinds of micellar nanocarriers (MPEG-SS-CPT/DOX) with polyethylene glycol (PEG) based on the self-assembly glutathione (GSH)-responsive amphiphilic PEGylated polymers (MPEG-SS-CPT) in free doxorubicin (DOX) solution, which could carry anticancer drugs camptothecin (CPT) and DOX toward cancer cells together. In vitro release studies, micelles MPEG-SS-CPT/DOX undergo triggered disassembly CPT under GSH stimulus much faster than without GSH. Furthermore, MPEG-SS-CPT no change its original structure after degradation. From experiments loading drugs, cell viability assay, cellular uptake, flow cytometry it was found that fibrous modified by PEG molecular weight 350 had greater potential field drug delivery other 1900.
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