Plasma transforming growth factor β1 as a predictor of radiation pneumonitis

摘要: Abstract Purpose: To investigate prospectively the utility of plasma transforming growth factor β1 (TGFβ1) as a marker for development symptomatic radiation pneumonitis. Materials and Methods: Seventy-three patients with lung cancer treated curative intent are reported herein. Plasma TGFβ1 samples were obtained before, weekly during, at each follow-up after therapy (RT). was extracted using an acid/ethanol method. An enzyme-linked immunosorbent assay used to quantify concentrations. The level end RT considered “normal” if it both ≤ 7.5 ng/ml less than pretreatment value. All followed least 6 months, unless pneumonitis developed sooner. Pneumonitis defined by National Cancer Institute (NCI) common toxicity criteria. Results: Fifteen 73 (21%) remaining 58 (79%) did not. A normal RT, above, more in who not develop return accurately identified would sensitivity positive predictive value 90%. Conclusion: levels appear be useful means identify low risk from thoracic RT. Thus, monitoring may candidates dose escalation studies treatment cancer.