Effectiveness of Lactobacillus reuteri in infantile colic and colicky induced maternal depression: a prospective single blind randomized trial.

摘要: Infant colic, excessive crying of unknown cause, is a major burden to families and effects about 10–30 % infants. Despite decades research, the exact cause treatment infant colic has remained elusive. The use Lactobacillus reuteri (DSM 17938) in somewhat controversial hence, we designed this study evaluate its efficacy infantile colic. We recruited predominantly or exclusively breastfed infants, aged less than 4 months placebo controlled observational randomized study. Participants’ were assigned receive L. at dose 108 colony forming units (n = 21) (n = 21). Placebo was an identical formulation without live micro-organisms. Treatment given subjects for 21 days they followed 4 weeks. success (primary outcome), daily reduction time, parent satisfaction maternal depression (secondary outcomes) assessed end period. observed all infants (100 %) probiotic group while it seen 15.7 % group. Mean time more significantly reduced 32.1 ± 8.3 min/day (P < 0.01) from 200.9 ± 6.3 min/day as compared (120.6 ± 20.0 min/day). Moreover, throughout period, parent’s improvement (Edinburgh postnatal scale) also higher In our population, significant even during first week initiation therapy. conclude that reduces suggest may be safe efficacious option reducing