Susceptibility and resistance of Sprague-Sawley and spontaneously hypertensive rats to aortic calcification induced by a diet high in CaP04

摘要: Male and female, Sprague--Dawley (S--D) spontaneously hypertensive rats (SHR) with arteriosclerosis (breeders) without (virgins) were fed a regular control diet or high in CaPO4. After 45 days on the Ca : P diet, there no obvious adverse effects health, body, organ weights of any animals. Although did not cause exacerbation spontaneous blood pressure SHR, it hyperlipidemia abnormally elevated corticosterone levels, but paradoxically, low normal levels circulating P. Despite fact that produces kidney stones, was increase incidence stones which appear breeder rats. The alter intimal hyalin lesions gonadal arterioles exclusively SHR breeders produce severe exacarbation aortic calcification appears repeatedly bred, S--D