Neuroblastoma is composed of two super-enhancer-associated differentiation states
作者： Tim van Groningen , Jan Koster , Linda J Valentijn , Danny A Zwijnenburg , Nurdan Akogul
DOI: 10.1038/NG.3899
关键词:
摘要: Neuroblastoma and other pediatric tumors show a paucity of gene mutations, which has sparked an interest in their epigenetic regulation. Several tumor types include phenotypically divergent cells, resembling cells from different lineage development stages. It been proposed that super-enhancer-associated transcription factor (TF) networks underlie identity, but the role these enhancers intratumoral heterogeneity is unknown. Here we most neuroblastomas two with expression profiles. Undifferentiated mesenchymal committed adrenergic can interconvert resemble differentiation ChIP-seq analysis isogenic pairs identified distinct super-enhancer landscape TF network for each cell type. Expression PRRX1 could reprogram mRNA landscapes toward state. Mesenchymal were more chemoresistant vitro enriched post-therapy relapse tumors. Two networks, probably mediate control normal development, thus dominate neuroblastoma shape heterogeneity.
vumc.nl
narcis.nl
nature.com
core.ac.uk 参考文章(30)
Richard A. Young, Control of the Embryonic Stem Cell State Cell. ,vol. 144, pp. 940- 954 ,(2011) , 10.1016/J.CELL.2011.01.032
Lucia Ricci-Vitiani, Dario G. Lombardi, Emanuela Pilozzi, Mauro Biffoni, Matilde Todaro, Cesare Peschle, Ruggero De Maria, Identification and expansion of human colon-cancer-initiating cells Nature. ,vol. 445, pp. 111- 115 ,(2007) , 10.1038/NATURE05384
A. P. Patel, I. Tirosh, J. J. Trombetta, A. K. Shalek, S. M. Gillespie, H. Wakimoto, D. P. Cahill, B. V. Nahed, W. T. Curry, R. L. Martuza, D. N. Louis, O. Rozenblatt-Rosen, M. L. Suva, A. Regev, B. E. Bernstein, Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma Science. ,vol. 344, pp. 1396- 1401 ,(2014) , 10.1126/SCIENCE.1254257
Neville E Sanjana, Ophir Shalem, Feng Zhang, Improved vectors and genome-wide libraries for CRISPR screening. Nature Methods. ,vol. 11, pp. 783- 784 ,(2014) , 10.1038/NMETH.3047
Laurel T. Bate-Eya, Marli E. Ebus, Jan Koster, Ilona J.M. den Hartog, Danny A. Zwijnenburg, Linda Schild, Ida van der Ploeg, M. Emmy M. Dolman, Huib N. Caron, Rogier Versteeg, Jan J. Molenaar, Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours European Journal of Cancer. ,vol. 50, pp. 628- 637 ,(2014) , 10.1016/J.EJCA.2013.11.015
Mario L. Suvà, Esther Rheinbay, Shawn M. Gillespie, Anoop P. Patel, Hiroaki Wakimoto, Samuel D. Rabkin, Nicolo Riggi, Andrew S. Chi, Daniel P. Cahill, Brian V. Nahed, William T. Curry, Robert L. Martuza, Miguel N. Rivera, Nikki Rossetti, Simon Kasif, Samantha Beik, Sabah Kadri, Itay Tirosh, Ivo Wortman, Alex K. Shalek, Orit Rozenblatt-Rosen, Aviv Regev, David N. Louis, Bradley E. Bernstein, Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells Cell. ,vol. 157, pp. 580- 594 ,(2014) , 10.1016/J.CELL.2014.02.030
Alvaro Rada-Iglesias, Ruchi Bajpai, Sara Prescott, Samantha A. Brugmann, Tomek Swigut, Joanna Wysocka, Epigenomic Annotation of Enhancers Predicts Transcriptional Regulators of Human Neural Crest Cell Stem Cell. ,vol. 11, pp. 633- 648 ,(2012) , 10.1016/J.STEM.2012.07.006
Zhenqiang Su, Paweł P Łabaj, Sheng Li, Jean Thierry-Mieg, Danielle Thierry-Mieg, Wei Shi, Charles Wang, Gary P Schroth, Robert A Setterquist, John F Thompson, Wendell D Jones, Wenzhong Xiao, Weihong Xu, Roderick V Jensen, Reagan Kelly, Joshua Xu, Ana Conesa, Cesare Furlanello, Hanlin Gao, Huixiao Hong, Nadereh Jafari, Stan Letovsky, Yang Liao, Fei Lu, Edward J Oakeley, Zhiyu Peng, Craig A Praul, Javier Santoyo-Lopez, Andreas Scherer, Tieliu Shi, Gordon K Smyth, Frank Staedtler, Peter Sykacek, Xin-Xing Tan, E Aubrey Thompson, Jo Vandesompele, May D Wang, Jian Wang, Russell D Wolfinger, Jiri Zavadil, Scott S Auerbach, Wenjun Bao, Hans Binder, Thomas Blomquist, Murray H Brilliant, Pierre R Bushel, Weimin Cai, Jennifer G Catalano, Ching-Wei Chang, Tao Chen, Geng Chen, Rong Chen, Marco Chierici, Tzu-Ming Chu, Djork-Arne Clevert, Youping Deng, Adnan Derti, Viswanath Devanarayan, Zirui Dong, Joaquin Dopazo, Tingting Du, Hong Fang, Yongxiang Fang, Mario Fasold, Anita Fernandez, Matthias Fischer, Pedro Furio-Tari, James C Fuscoe, Florian Caimet, Stan Gaj, Jorge Gandara, Huan Gao, Weigong Ge, Yoichi Gondo, Binsheng Gong, Meihua Gong, Zhuolin Gong, Bridgett Green, Chao Guo, Lei Guo, Li-Wu Guo, James Hadfield, Jan Hellemans, Sepp Hochreiter, Meiwen Jia, Min Jian, Charles D Johnson, Suzanne Kay, Jos Kleinjans, Samir Lababidi, Shawn Levy, Quan-Zhen Li, Li Li, Peng Li, Yan Li, Haiqing Li, Jianying Li, Shiyong Li, Simon M Lin, Francisco J López, Xin Lu, Heng Luo, Xiwen Ma, Joseph Meehan, Dalila B Megherbi, Nan Mei, Bing Mu, Baitang Ning, Akhilesh Pandey, Javier Pérez-Florido, Roger G Perkins, Ryan Peters, John H Phan, Mehdi Pirooznia, Feng Qian, Tao Qing, Lucille Rainbow, Philippe Rocca-Serra, Laure Sambourg, Susanna-Assunta Sansone, Scott Schwartz, Ruchir Shah, Jie Shen, Todd M Smith, Oliver Stegle, Nancy Stralis-Pavese, Elia Stupka, Yutaka Suzuki, Lee T Szkotnicki, Matthew Tinning, Bimeng Tu, Joost Van Delft, Alicia Vela-Boza, Elisa Venturini, Stephen J Walker, Liqing Wan, Wei Wang, Jinhui Wang, Jun Wang, Eric D Wieben, James C Willey, Po-Yen Wu, Jiekun Xuan, Yong Yang, Zhan Ye, Ye Yin, Ying Yu, Yate-Ching Yuan, John Zhang, Ke K Zhang, A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium Nature Biotechnology. ,vol. 32, pp. 903- 914 ,(2014) , 10.1038/NBT.2957
L. Cong, F. A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib, P. D. Hsu, X. Wu, W. Jiang, L. A. Marraffini, F. Zhang, Multiplex Genome Engineering Using CRISPR/Cas Systems Science. ,vol. 339, pp. 819- 823 ,(2013) , 10.1126/SCIENCE.1231143
Jens Bunt, Nancy E. Hasselt, Danny A. Zwijnenburg, Jan Koster, Rogier Versteeg, Marcel Kool, Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma PLOS ONE. ,vol. 6, ,(2011) , 10.1371/JOURNAL.PONE.0026058