Absence of liver DNA fragmentation in rats treated with high oral doses of 32 benzodiazepine drugs

摘要: Abstract Literature data on mutagenic-carcinogenic activity of benzodiazepines are scarce, restricted to few them, and contradictory. Consequently, in order provide additional information for the assessment genotoxic risk connected with use this family drugs, 32 various chemical structure have been tested their capability induce DNA damage vivo , which is considered a sensitive index potential activity. The frequency single-strand breaks and/or alkali-labile sites was checked liver rats given orally single dose (1 mmol/kg) or 15 successive daily doses (0.2 by new viscometric technique capable detecting one lesion per 10 Da. Statistically significant changes parameters indicative fragmentation were absent all benzodiazepines, after both acute subacute treatments. Since from 100 more than 5000 times higher usually administered humans, these negative results favor absence effects patients taking benzodiazepines.