Two-drug therapy in patients with metastatic germ cell tumors

摘要: Eighty-two patients with metastatic germ cell tumors (GCT) treated two-drug therapy consisting of etoposide and cisplatin were evaluated for late relapse. Good-risk GCT was defined using Memorial Sloan-Kettering Cancer Center (MSKCC) criteria. Etoposide given at 100 mg/m2 on days 1 to 5 20 5; recycled 21 delays up 7 a leukocyte count less than 3000/microliters or platelet 100,000/microliters. Drug doses not attenuated myelosuppression. Seventy-six 82 evaluable achieved complete response (CR). Seventy-two had CR chemotherapy alone. Forty-six (56%) excision residual abnormalities: 11 teratoma in the resected specimen, 31 necrotic debris fibrosis, 4 after plus viable GCT. Six an incomplete chemotherapy; one these unresectable mature remains progression-free. The median dose (+/- standard deviation [SD]) 500 mg/m2/course 35 mg/m2) SD) 6 mg/m2). Nine experienced relapse 17.5 months; two nonseminomatous salvaged by patient seminoma radiation therapy. three who additional are disease-free 59 63 months. Seventy-one (87%) remain follow-up time months (range, 33 92 months). No relapses have occurred beyond schedule results durable without