Systemic therapy with immunosuppressive agents and retinoids in hidradenitis suppurativa: a systematic review

摘要: Hidradenitis suppurativa (HS) is a difficult disease to treat. Although the pathogenesis of this inflammatory skin largely unknown, important role immune system has been demonstrated in both experimental and clinical studies. Clinicians are therefore increasingly prescribing systemic treatments with immunosuppressive agents, but more traditionally used retinoids, especially isotretinoin, also remain relatively common therapies. In order provide an overview all currently available agents retinoids for treatment HS, systematic search was performed using Medline Embase databases. All published papers concerning or HS adults were included. The primary endpoints percentages significant responders, moderate responders nonresponders. Other relapse rate adverse events. total 87 included, comprising 518 patients who treated biological another including colchicine, ciclosporin, dapsone methotrexate. highest response rates observed infliximab, adalimumab acitretin. Overall, quality evidence low differed between making direct comparisons difficult. However, based on amount evidence, infliximab most effective agents. Acitretin although low. therapeutic effect isotretinoin questionable. Randomized controlled trials needed confirm effectiveness acitretin, identify HS.