Systemic Injection of Kainic Acid Differently Affects LTP Magnitude Depending on its Epileptogenic Efficiency

摘要: Seizures have profound impact on synaptic function and plasticity. While kainic acid is a popular method to induce seizures potentially affect plasticity, it can also produce physiological-like oscillations trigger some forms of long-term potentiation (LTP). Here, we examine whether induction LTP altered in hippocampal slices prepared from rats with different sensitivity develop status epilepticus (SE) by systemic injection acid. Rats were treated multiple low doses (5 mg/kg; i.p.) SE majority animals (72–85% rats). A group resistant (15–28%) after several accumulated doses. Animals subsequently tested using chronic recordings object recognition tasks before brain for histological studies basic features including input/output curves, paired-pulse facilitation theta-burst induced LTP. Consistent previous reports kindling pilocapine models, was reduced that developed injection. These exhibited signs sclerosis spontaneous seizures. In contrast, did not become epileptic had no cell loss mossy fiber sprouting. rats, stimulation higher magnitude when compared control rats. Variations correlate animals’ performance hippocampal-dependent spatial memory task. Our results suggest dissociable effects treatment plasticity depending its epileptogenic efficiency.