Nanostructured mesoporous bioglass coated zirconia scaffolds for bone tissue engineering

摘要: For the filling and reconstruction of non-healing bone defects, application porous ceramic scaffold as substitutes is considered to be a reasonable choice. In tissue engineering, an ideal must satisfy several criterias such open porosity, having high compressive strength (it depends where in body, if external fixatures are used) practicability for cell migration. Many researchers have focused on enhancing mechanical properties hydroxyapatite scaffolds by combining it with other biomaterials, bioglass polymers. Nevertheless, there still lack suitable based biomaterials. this study, zirconia from two different templates (polyurethane (PU) Acrylonitrile Butadiene Styrene (ABS) templates) were successfully fabricated dissimilar fabrication techniques. The surfaces further modified mesoporous purpose engineering. study PU template scaffold, porosity (~88%) sol-gel derived yttria-stabilized (YSZ) was prepared polyurethane foam replica method using first time, double coated Mesoporous Bioglass (MBGs) coating. ABS types (cube cylinder) strut spacings used 3D Rapid Prototyper. Subsequently, low (63±2.8% 68±2.5%) embedding powder slurry into burning out produce uniform structure. dip coating time. porosities calculated before after microstructures then examined scanning electron microscopy evaluated test. Accordingly, relationships between microstructure, processing behaviour discussed. Scaffold biocompatibility bioactivity also marrow stromal (BMSC) proliferation test simulated body fluid