Hepatocellular carcinoma: surgical resection versus surgical resection combined with pre- and post-operative locoregional immunotherapy-chemotherapy. A prospective randomized study.

摘要: Abstract Hepatocellular carcinoma remains a disease with poor prognosis. Liver resection, although the optimal method of management, is associated high incidence intrahepatic tumour recurrence ranging between 50-70%, 12 to 18 months following surgery. This study assesses prospectively results liver resection as compared combined pre- and post-operative locoregional chemotherapy-immunotherapy in 40 patients suffering from hepatocellular carcinoma. Patients were randomly assigned two groups. Group A (20 patients) had only, while B past-operative targeting chemotherapy-immunotherapy. Five (5) died total: B, during first 30 days surgery due reasons related procedure (post-operative failure three, pulmonary embolism one). The remaining patient 10 recurrence. From A, 17 are alive 3 26 after Of patients, free 7 show Thus, occurred 8 group A. all 4 27 No because nor has any shown As conclusion present results, immunotherapy-chemotherapy appears offer substantial advantages for undergoing