A Systematic Review of Hepatic Artery Chemotherapy After Hepatic Resection of Colorectal Cancer Metastatic to the Liver

摘要: Colorectal cancer metastatic to the liver, when technically feasible, is resected with a moderate chance of cure. The most common site failure after resection in remaining liver. To enhance survival, chemotherapy has been delivered directly liver postresection via hepatic artery. This study was designed assess effect posthepatic resection, artery on overall survival. Trials were sought Medline, Cochrane Controlled Trial Register, Hepatobiliary Group and through contact trial authors reference lists using key words: colorectal, cancer, metastases, artery, chemotherapy, randomized. chosen which patients having colorectal randomized or any alternative treatment. Survival data obtained principally from abstraction survival curves published studies method Parmar calculate study-specific, log-hazard ratio then combined-effect, ratio, as well combined Kaplan-Meier probability curve. Overall at five years group 45 percent 40 control group. Forty-three individuals developed recurrent metastases group, 97 recurrence However, no significant advantage found meta-analysis for measuring calculating based “intention treat” (log-hazard = 0.0848, favoring group; 95 confidence interval ±0.2037). Adverse events related therapy common, including therapy-related deaths. Although happened less frequently not improved. even favored although significantly. added intervention treatment cannot be recommended this time.