The Pathogenesis of Salt-Sensitive Hypertension

摘要: Patients with normal plasma renin and essential hypertension can be divided into two groups according to blood pressure response salt loading; salt-sensitive (SS) non-salt-sensitive (NSS). With a high-sodium diet SS patients retained more sodium, had greater increase in cardiac output, as compared NSS patients. Despite the markedly increased systemic vascular resistance did not change sodium loads patients, suggesting inappropriately elevated resistance. The seems characterized by very inhomogeneous distribution of local flow patients; renal hepatic remains essentially unchanged skeletal muscle receives almost all output. Moreover, changes reflect individual beds because vasoconstriction appeared kidney splanchnic area but was masked prominent vasodilation muscle. Because this hemodynamic pattern is similar evoked during defense reaction, it suggested that sympathetic overactivity on selective basis might involved impaired function for excretion